Post doc

Tala Al Tabosh

Is a vascular biology researcher whose work focuses on the cellular and molecular mechanisms governing endothelial homeostasis and rare vascular diseases. A recipient of the IdEx and Marie Skłodowska-Curie scholarships, she completed her PhD at the University of Grenoble Alpes (UMR 1292, CEA Grenoble) within the European V.A. Cure network, where she characterized the impact of heterozygous ALK1 mutations on the transcriptomic responses of endothelial cells from patients with hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension, enhancing our understanding of the molecular mechanisms underlying these diseases. She is currently conducting her research at the BioTis laboratory (Inserm U1026, Bordeaux) in the team of Dr. Elisabeth Génot, where she investigates potential curative strategies for fibrillin-1 deficiency in the context of Marfan syndrome and investigates interactions between endothelial cells, the extracellular matrix, and vascular remodeling. With extensive expertise in cellular and molecular biology, functional assays, and advanced imaging, she employs both in vitro and ex vivo models to dissect vascular wall dynamics and propose innovative approaches for tissue repair. Her work, published in international journals such as Journal of Clinical Investigation, Angiogenesis, and Cells, aims to elucidate the determinants of vascular dysfunction and contribute to the development of targeted therapies for rare and degenerative vascular diseases