Principal investigator

Trained both in biology in and biochemistry at the Curie Institute in Paris, received her PhD at the University Pierre & Marie Curie in 1988. Starting her career in Immunology, she worked on the regulation of B lymphocyte expansion during the immune response and on the molecular mechanisms underlying Hairy Cell Leukemia oncogenicity. She trained in signal transduction at the University of Washington in Seattle (USA) under the guidance of Ed. Clark and Ed. Krebs. Thereafter, she focused her work on intracellular signalling involving the RhoGTPase family of proteins during T lymphocyte activation at Imperial Cancer research Fund (London, UK). In 1998, she became the recipient of Career Development Award from the Welcome Trust to set up her lab at Imperial College (Hammersmith Hospital, London, UK). There she continued this line of research focusing on apoptosis as well. She joined the European Institute of Chemistry and Biology (IECB) in Bordeaux (France) as a group leader in 2002. Since then, her main research field is endothelial cell biology from microvessels to large arteries, in vitro and in vivo, with a focus on the dynamical rearrangements of the actin cytoskeleton and specific expertise on podosomes. She is a board member of the Invadosome Consortium, an international, open network of laboratories interested in cell adhesion and tissue invasion. She is also involved in interdisciplinary and collaborative work with chemists, microbiologists and clinicians and actively participating to the development of the new Institute for Regenerative Medicine (BxCRM) in Bordeaux. Elisabeth Génot is affiliated with the Department of Regenerative Medicine (BioTis, INSERM U1026) where she holds an INSERM research director position.

Team members

Alumni

Since 2000, the Génot lab  has trained many students and young scientists. The team  is maintaining collaborations with some of them such as Christine Varon (INSERM U1053, Université de Bordeaux, France),  Pirjo Spuul (Tallinn University of technology, Estonia) and Florence Tatin (I2MC INSERM UMR 1048, Université Paul Sabatier, Toulouse, France).

Past members

Trainees / Internship