Research Output



Peer-reviewed articles and textbooks











Dong Y, Alonso F, Jahjah T, Fremaux I, Grosset CF, Génot E. miR-155 regulates physiological angiogenesis but an miR-155-rich microenvironment disrupts the process by promoting unproductive endothelial sprouting. Cell Mol Life Sci. 2022 Mar 26;79(4):208. doi: 10.1007/s00018-022-04231-3.


Alonso F, Dong Y, Génot E. Thrombomodulin, an Unexpected New Player in Endothelial Cell Invasion During Angiogenesis. Arterioscler Thromb Vasc Biol. 2021 May 5;41(5):1672-1674. doi: 10.1161/ATVBAHA.121.316205.


Quideau S, Delannoy López DM, Tran DT, Viault G, Dairi S, Peixoto PA, Capello Y, Minder L, Pouységu L, Génot E, Di Primo C, Deffieux D. Real-Time Analysis of Polyphenol-Protein Interactions by Surface Plasmon Resonance Using Surface-Bound Polyphenols. Chemistry. 2021 Jan 14. doi: 10.1002/chem.202005187.


Zagryazhskaya-Masson A, Monteiro P, Macé AS, Castagnino A, Ferrari R, Infante E, Duperray-Susini A, Dingli F, Lanyi A, Loew D, Génot E, Chavrier P. Intersection of TKS5 and FGD1/CDC42 signaling cascades directs the formation of invadopodia. J Cell Biol. 2020 Sep 7;219(9):e201910132.


Alonso F, Spuul P, Decossas M, Egaña I, Curado F, Fremaux I, Daubon T, Génot E. Regulation of podosome formation in aortic endothelial cells by physiological extracellular cues. Eur J Cell Biol. 2020 May;99(4):151084.


Benn A, Alonso F, Mangelschots J, Génot E, Lox M, Zwijsen A. BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development. Biomolecules. 2020 Mar 23;10(3):488.


Alonso F, Spuul P, Génot E. Podosomes in endothelial cell–microenvironment interactions. Curr Opin Hematol. 2020 May;27(3):197-205.


Rémy M, Ferraro F, Le Salver P, Rey S, Genot E, Djavaheri-Mergny M, Thébaud N, Boiziau C, Boeuf H. Isolation and Culture of Human Stem Cells from Apical Papilla under Low Oxygen Concentration Highlight Original Properties. Cells. 2019 Nov 21;8(12):1485.


Chi PY, Spuul P, Tseng FG, Genot E, Chou CF, Taloni A. Cell Migration in Microfluidic Devices: Invadosomes Formation in Confined Environments. Adv Exp Med Biol. 2019;1146:79-103.


Alonso F, Spuul P, Daubon T, Kramer I, Génot E. Variations on the theme of podosomes: A matter of context.Biochim Biophys Acta Mol Cell Res. 2019 Apr;1866(4):545-553.



Georgess D, Spuul P, Le Clainche C, Le Nihouannen D, Fremaux I, Dakhli T, Delannoy López DM, Deffieux D, Jurdic P, Quideau S, Génot E. Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation.  Eur J Cell Biol. 2018 Nov;97(8):533-545.


Alonso F, Spuul P, Kramer I, Génot E. Med Sci (Paris). Variations on the theme of podosomes, context matters. 2018 Dec;34(12):1063-1070.


Haefliger J, Allagnat A, Hamard L, Le Gal L, Nardelli-Haefliger D, Meda P, Génot E, Alonso F. Targeting Connexin40 expression or function reduces angiogenesis in the developing mouse retina. Arterioscler Thromb Vasc Biol. 2017 Oct 5. pii: ATVBAHA.117.310072.


Pujol F, Hodgson T, Martinez-Corral I, Prats AC, Devenport D, Takeichi M, Génot E, Mäkinen T, Francis-West P, Garmy-Susini B, Tatin F. Dachsous1-Fat4 signaling controls endothelial cell polarization during lymphatic valve morphogenesis. Arterioscler Thromb Vasc Biol. 2017 Jul 13. pii: ATVBAHA.117.309818.


Génot E. ARF1 at the crossroads of podosome construction and function. J Cell Biol. 2017 Jan 2;216(1):13-15.


Kramer I.M. & Kusurkar RScience-writing in the blogosphere as a tool to promote autonomous motivation in education. The Internet and Higher Education. 2017, 35: 48-62.


Spuul P, Daubon T, Pitter B, Alonso F, Fremaux I, Kramer I, Montanez E, Génot E. VEGF-A/Notch-Induced Podosomes Proteolyse Basement Membrane Collagen-IV during Retinal Sprouting Angiogenesis. Cell Rep. 2016 Oct 4;17(2):484-500.


Daubon T, Spuul P, Alonso F, Fremaux I, Génot E. VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells. J Cell Sci. 2016 Jul 1;129(13):2586-98. – Journal issue cover illustration. – Editorial highlight. 


Spuul P, Chi PY, Billottet C, Chou CF, Génot E. Microfluidic devices for the study of actin cytoskeleton in constricted environments: Evidence for podosome formation in endothelial cells exposed to a confined slit. Methods. 2016 Feb 1;94:65-74. – Journal issue cover illustration.


Leclercq A, Veillat V, Loriot S, Spuul P, Madonna F, Roques X, Génot E. A Methodology for Concomitant Isolation of Intimal and Adventitial Endothelial Cells from the Human Thoracic Aorta. PLoS One. 2015 Nov 24;10(11):e0143144.


Veillat V, Spuul P, Daubon T, Egaña I, Kramer I, Génot E. Podosomes: Multipurpose organelles? Int J Biochem Cell Biol. 2015 Aug;65:52-60.


Aubert L, Guilbert M, Corbet C, Génot E, Adriaenssens E, Chassat T, Bertucci F, Daubon T, Magné N, Le Bourhis X, Toillon RA. NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib. Oncotarget. 2015;6(12):9807-19.


Génot E, Gligorijevic B. Invadosomes in their natural habitat. Eur J Cell Biol. 2014 Oct;93(10-12):367-79.


Klingberg F, Chow ML, Koehler A, Boo S, Buscemi L, Quinn TM, Costell M, Alman BA, Génot E, Hinz B. Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation. J Cell Biol. 2014 Oct 27;207(2):283-97.


Curado F, Spuul P, Egaña I, Rottiers P, Daubon T, Veillat V, Duhamel P, Leclercq A, Gontier E, Génot E. ALK5 and ALK1 play antagonistic roles in transforming growth factor β-induced podosome formation in aortic endothelial cells. Mol Cell Biol. 2014 Dec;34(24):4389-403.  – Journal issue cover illustration.


Seano G, Daubon T, Génot E, Primo L. Podosomes as novel players in endothelial biology. Eur J Cell Biol. 2014 Oct;93(10-12):405-12.


Spuul P, Ciufici P, Veillat V, Leclercq A, Daubon T, Kramer IJ, Génot E. Importance of RhoGTPases in formation, characteristics, and functions of invadosomes. Small GTPases. 2014;5:e28195.


Génot E, Daubon T, Sorrentino V, Buccione R. FGD1 as a central regulator of extracellular matrix remodelling–lessons from faciogenital dysplasia. J Cell Sci. 2012 Jul 15;125(Pt 14):3265-70. – Journal issue cover illustration.


Daubon T, Rochelle T, Bourmeyster N, Génot E. Invadopodia and rolling-type motility are specific features of highly invasive p190(bcr-abl) leukemic cells. Eur J Cell Biol. 2012 Nov-Dec;91(11-12):978-87.


Le Roux-Goglin E, Varon C, Spuul P, Asencio C, Mégraud F, Génot E. Helicobacter infection induces podosome assembly in primary hepatocytes in vitro. Eur J Cell Biol. 2012 Mar;91(3):161-70. – Journal issue cover illustration.


Juin A, Billottet C, Moreau V, Destaing O, Albiges-Rizo C, Rosenbaum J, Génot E, Saltel F. Physiological type I collagen organization induces the formation of a novel class of linear invadosomes. Mol Biol Cell. 2012 Jan;23(2):297-309. – Journal issue cover illustration.


Daubon T, Buccione R, Génot E. The Aarskog-Scott syndrome protein Fgd1 regulates podosome formation and extracellular matrix remodeling in transforming growth factor β-stimulated aortic endothelial cells. Mol Cell Biol. 2011 Nov;31(22):4430-41.


Quideau S, Douat-Casassus C, Delannoy López DM, Di Primo C, Chassaing S, Jacquet R, Saltel F, Génot E. Binding of filamentous actin and winding into fibrillar aggregates by the polyphenolic C-glucosidic ellagitannin vescalagin. Angew Chem Int Ed Engl. 2011 May 23;50(22):5099-104. 2011 Apr 27.


Kremerskothen J, Stölting M, Wiesner C, Korb-Pap A, van Vliet V, Linder S, Huber TB, Rottiers P, Reuzeau E, Génot E, Pavenstädt H. Zona occludens proteins modulate podosome formation and function. FASEB J. 2011 Feb;25(2):505-14.  2010 Oct 7.


Saltel F, Daubon T, Juin A, Ganuza IE, Veillat V, Génot E. Invadosomes: intriguing structures with promise. Eur J Cell Biol. 2011 Feb-Mar;90(2-3):100-7. Review.

    Pre – 2011

Tatin F, Grise F, Reuzeau E, Génot E, Moreau V. Sodium fluoride induces podosome formation in endothelial cells. Biol Cell. 2010 Jul 6;102(9):489-98.


Smolková K, Bellance N, Scandurra F, Génot E, Gnaiger E, Plecitá-Hlavatá L, Jezek P, Rossignol R. Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia. J Bioenerg Biomembr. 2010 Feb;42(1):55-67.


Rottiers P, Saltel F, Daubon T, Chaigne-Delalande B, Tridon V, Billottet C, Reuzeau E, Génot E. TGFbeta-induced endothelial podosomes mediate basement membrane collagen degradation in arterial vessels. J Cell Sci. 2009 Dec 1;122(Pt 23):4311-8. – Highlight in Nature Review Molecular Cell Biology, Journal club, Vol 11, April 2010


Génot E. [The endothelial podosome]. Med Sci (Paris). 2009 Feb;25(2):168-74.


Guegan F, Tatin F, Leste-Lasserre T, Drutel G, Génot E, Moreau V. p190B RhoGAP regulates endothelial-cell-associated proteolysis through MT1-MMP and MMP2. J Cell Sci. 2008 Jun 15;121(Pt 12):2054-61. 2008 May 27.


Billottet C, Rottiers P, Tatin F, Varon C, Reuzeau E, Maître JL, Saltel F, Moreau V, Génot E. Regulatory signals for endothelial podosome formation. Eur J Cell Biol. 2008 Sep;87(8-9):543-54.


Varon C, Rottiers P, Ezan J, Reuzeau E, Basoni C, Kramer I, Génot E. TGFbeta1 regulates endothelial cell spreading and hypertrophy through a Rac-p38-mediated pathway. Biol Cell. 2008 Sep;100(9):537-50.


Chaigne-Delalande B, Anies G, Kramer I, Génot E. Nonadherent cells switch to a Rac-mediated, SHIP regulated, Akt activation mode for survival. Oncogene. 2008 Mar 20;27(13):1876-85. 2007 Oct 1.


Chabadel A, Bañon-Rodríguez I, Cluet D, Rudkin BB, Wehrle-Haller B, Génot E, Jurdic P, Anton IM, Saltel F. CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts. Mol Biol Cell. 2007 Dec;18(12):4899-910.


Mondin M, Moreau V, Génot E, Combe C, Ripoche J, Dubus I. Alterations in cytoskeletal protein expression by mycophenolic acid in human mesangial cells requires Rac inactivation. Biochem Pharmacol. 2007 May 1;73(9):1491-8.


Varon C, Basoni C, Reuzeau E, Moreau V, Kramer IJ, Génot E. TGFbeta1-induced aortic endothelial morphogenesis requires signaling by small GTPases Rac1 and RhoA. Exp Cell Res. 2006 Nov 1;312(18):3604-19.


Varon C, Tatin F, Moreau V, Van Obberghen-Schilling E, Fernandez-Sauze S, Reuzeau E, Kramer I, Génot E. Transforming growth factor beta induces rosettes of podosomes in primary aortic endothelial cells. Mol Cell Biol. 2006 May;26(9):3582-94.


Basoni C, Reuzeau E, Croft D, Génot E, Kramer IM. CD44 and TGFbeta1 synergise to induce expression of a functional NADPH oxidase in promyelocytic cells. Biochem Biophys Res Commun. 2006 May 5;343(2):609-16.


Moreau V, Tatin F, Varon C, Anies G, Savona-Baron C, Génot E. Cdc42-driven podosome formation in endothelial cells. Eur J Cell Biol. 2006 Apr;85(3-4):319-25.


Tatin F, Varon C, Génot E, Moreau V. A signalling cascade involving PKC, Src and Cdc42 regulates podosome assembly in cultured endothelial cells in response to phorbol ester. J Cell Sci. 2006 Feb 15;119(Pt 4):769-81.


Chaigne-Delalande B, Deuve L, Reuzeau E, Basoni C, Lafarge D, Varon C, Tatin F, Anies G, Garand R, Kramer I, Génot E. RhoGTPases and p53 are involved in the morphological appearance and interferon-alpha response of hairy cells. Am J Pathol. 2006 Feb;168(2):562-73.


Basoni C, Nobles M, Grimshaw A, Desgranges C, Davies D, Perretti M, Kramer IM, Génot E. Inhibitory control of TGF-beta1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes. FASEB J. 2005 May;19(7):822-4.


Renault MA, Jalvy S, Potier M, Belloc I, Génot E, Dekker LV, Desgranges C, Gadeau AP. UTP induces osteopontin expression through a coordinate action of NFkappaB, activator protein-1, and upstream stimulatory factor in arterial smooth muscle cells. J Biol Chem. 2005 Jan 28;280(4):2708-13.


Kramer I, Wibulswas A, Croft D, Génot E. Rheumatoid arthritis: targeting the proliferative fibroblasts. Prog Cell Cycle Res. 2003;5:59-70.


Moreau V, Tatin F, Varon C, Génot E. Actin can reorganize into podosomes in aortic endothelial cells, a process controlled by Cdc42 and RhoA. Mol Cell Biol. 2003 Oct;23(19):6809-22.


Wibulswas A, Croft D, Pitsillides AA, Bacarese-Hamilton I, McIntyre P, Génot E, Kramer IM. Influence of epitopes CD44v3 and CD44v6 in the invasive behavior of fibroblast-like synoviocytes derived from rheumatoid arthritic joints. Arthritis Rheum. 2002 Aug;46(8):2059-64.


Wibulswas A, Croft D, Bacarese-Hamilton I, McIntyre P, Génot E, Kramer IM. The CD44v7/8 epitope as a target to restrain proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Am J Pathol. 2000 Dec;157(6):2037-44.


Génot EM, Arrieumerlou C, Ku G, Burgering BM, Weiss A, Kramer IM. The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase. Mol Cell Biol. 2000 Aug;20(15):5469-78.


Génot E, Cantrell DA. Ras regulation and function in lymphocyt. Curr Opin Immunol. 2000 Jun;12(3):289-94.